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Papaya fruits also contained a significant amount of lycopene and anticancer activities of papaya have been demonstrated in a number of in vitro studies. Unfortunately, there are conflicting findings on the lycopene-prostate cancer risk relationship and the preventive role of tomato products. Further, the preventive effect on prostate cancer risk was found for a diet, which was rich in tomato products and lycopene. An inverse association between high intake of vegetables and/or fruits and incidences of cancer was reported by a number of epidemiological studies.
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Diet rich in high-fat milk and red meat, saturated fats and omega-6 fatty acids was found to increase the risk of prostate cancer whereas diet rich in fruits and vegetable decreases the risk of prostate cancer. Reduced testosterone levels have been related to obesity, metabolic syndrome (MS), benign prostatic hypertrophy and even prostate cancer. Sex hormones are also involved in prostate cancer development. Obesity also contributes to prostate cancer. In addition, a man who inherited the faulty BRCA2 gene is more likely to get the more severe type of prostate cancer. Also, a man who has a member of his family with prostate cancer is more likely to get the prostate cancer compared to another man. About 19% of black men, (1 in 5) will be diagnosed with prostate cancer, and 5% of those will die from this disease. In fact, prostate cancer is the fourth most common reason overall for death in African-American men. For example, men of African-American descent are at a significantly higher risk of developing prostate cancer than white men. The other contributing factor is genetics. The major factor contributing in prostate cancer is the age, because men who have the prostate cancer are between 65 and 80 years, and it is rare in men who are under than 40 years. The cases of cancer is expected to increase to 24 million by 2035, therefore, the death toll from cancer is expected to increase in the future. According to a report (2014) published by Cancer Research, UK, an estimated 14 million cases of cancer reported worldwide and nearly half-8.2 million people (about 13% of the total worldwide deaths) died from cancer. The prostate cancer is the malignant tumor of the prostate gland of male reproductive organ, which may be life threatening, when spread to other body parts, predominantly towards lymph nodes, and bones. The anticancer effect of black seeds may be because of their high concentration of polyphenols.Ĭonclusion: The black seeds from papaya may have a potential to reduce growth of prostate cells however, consumption of white seeds should be avoided as they may stimulate pre-existing prostate cancer. The data suggest that black seeds from papaya have anticancer effects on PCs whereas white seeds stimulated prostate cancer proliferation. The black seeds contained significantly more polyphenols than that of white seeds.
#Changing i doser doses computers Pc
However, the water-extract from white seeds stimulated PC cell proliferation. Results: The methanol extracts from black seeds significantly ( P < 0.05) decreased cell proliferation of PC-3 cells whereas hexane- and water-extracts have no effect.
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The amount of total polyphenols was determined using Folin Ciocalteu reagent. The cytotoxic effects of seeds extracts were determined using a WST-1 proliferation assay. Methods: The black seeds from yellow (ripe) papaya and white seeds from green (unripe) papaya were harvested and then extracted in water, 80% methanol, and hexane. Aim: The study investigated the effect of papaya seeds on prostate cancer (PC) using PC-3 cell line because papaya seeds have effects on the male reproductive system notably decreasing sperm concentration, motility, and viability, leading to azoospermia after short-to-long-term treatment.